The therapeutic versatility of antihistamines
نویسندگان
چکیده
منابع مشابه
Therapeutic Versatility of Resveratrol Derivatives
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متن کاملThe Value of a Broad Therapeutic Index for Antihistamines*
The therapeutic index of a histamine-1 (H1)antihistamine is the benefit-to-risk ratio of the medication and defines the range of doses and plasma concentrations over which the drug is effective and safe. In allergic rhinoconjunctivitis and urticaria, although the efficacy profiles of currently available H1-antihistamines are similar, these agents differ greatly with regard to safety, and this c...
متن کاملThe Comparative Effects of Four Antihistamines on Isolated Rat Atria
It has been reported that some of H1 receptor antagonists have important effects on cardiovascular system. Terfenadine as a non-sedative H1 receptor antagonist has an arrhythmogenic activity. In this study we have shown the effects of four antihistamine drugs: terfenadine, loratadine, clemastine and diphenhydramine, on the rate and contractions of isolated rat atria. Terfenadine (1-10 µM) cause...
متن کاملInteractions of the H1 antihistamines.
An interaction is taken to be the situation in which the administration of a drug or substance induces changes in the pharmacokinetics of another simultaneously administered drug – either increasing or decreasing the plasma concentration of the latter, and thus giving rise to the possibility of adverse reactions [1]. According to the primarily responsible pharmacological mechanism, H 1 antihist...
متن کاملAmbivalent antihistamines.
-In mice with a transplantable mammary carcinoma, treatment with the prostaglandin-synthesis inhibitors flurbiprofen or indomethacin produced various beneficial effects. Survival time after excision of the transplanted tumour was increased, particularly when the drugs were given with the chemotherapeutic agents methrotrexate and melphalan, and there were more disease-free survivors. The combine...
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ژورنال
عنوان ژورنال: The Nurse Practitioner
سال: 2020
ISSN: 0361-1817
DOI: 10.1097/01.npr.0000651112.76528.ed